The effect of intravenous Aminoplex 5 on serum gastrin and gastric secretion.

Material and methods Ten male volunteers without a history of abnormal gastric function, fasted for 10 hr overnight. A nasogastric tube was then passed and the resting juice aspirated. A 200 ml wash of water was instilled down the tube and immediately aspirated to check that the stomach was free of food debris and the tube was in the correct position. Gastric juice was then collected for a period of 3 hr by continuous suction at a negative pressure of 50 mmHg, interrupted approximately every 15 min for the injection of 20 ml of air down the tube to clear it of mucus. In the first hour normal saline was administered intravenously, via a small cannula inserted into an arm vein, at a rate of 50 drops/min (equivalent to 1 litre/6 hr).